Category
Artificial Intelligence

Will Data Science in Healthcare Overcome Its Many Roadblocks?

Data science now has an unprecedented opportunity to leverage machine learning and transform healthcare. Here's a look at how it can face up to some of its biggest challenges in the post-COVID era.

The potential for AI development to transform global healthcare culture from one of 'reactive disaster management' to one of 'prevention and early intervention' through predictive systems has become clear over the last ten years. The potential benefits remain compelling1,2, with the healthcare AI market forecast recently to reach US$51.3 billion by 20273.  

Possible applications and developments include:

  • Automation of medical imaging analysis4.
Medical image visualization and analysis in MATLAB
  • Identification of molecular biomarkers for disease, without biopsies, from simple fluid samples5.
A liquid biopsy system enabled by machine learning

  • Predictive health analytics (PHA) powering AI-based home monitoring systems6,7 for terminal and high-risk patients (a group representing just 5% of patients but 60% of healthcare costs in the US8).
  • Drug discovery, including prediction, design and drug-target interaction (DTI) phases9.
Training data assessment for drug discovery
  • Machine-driven analysis and logistical strategies for co-morbidities in chronic disease management (CDM)10.
  • Clinical trials for the identification of suitable candidates11; for the identification of biologics12 (large biological molecules) that may contribute to drug evolution for trials; and for ROI analysis13.
AI-based subject progress analysis in a clinical trial
  • New machine learning insights and applications related to epidemiology, including statistical prediction models14 and containment15.
  • The use of AI input for virtual, augmented and mixed reality (VAMR) in healthcare research, monitoring and palliative care16, as well as for adding an 'informed' VR layer to telesurgery procedures17.
  • AI in genomics research18,19.
  • AI-informed chatbots and engagement systems in the telehealth sector20

Systems and applications like this require access to patient data — perhaps the most politically and socially volatile topic in debates over the future of data science and machine learning. Since this represents a major impediment to progress21, and since it tends to dominate the discourse, let's examine the obstacles, and consider possible remedies.

Meet our data science practitioners
to collaborate on your project.

The Fragmented State of Healthcare Data

The World Health Organization has acknowledged22 the problems of scale and cost in transitioning healthcare data from paper to digital. Besides highly politicized issues around privacy (which we shall examine), the budgetary demands and long-term commitment needed to fulfil digitization strategies face a number of challenges:

  • The limited length of political administrations under pressure to achieve shorter-term victories.
  • Sporadic political manipulation of healthcare data23,24,25, which can render the data less accurate or representative, and adversely affect budget allocation for healthcare IT.
  • The limited fiscal resources26,27 of developing countries.
  • The way that US patient data is sub-divided between healthcare insurers28.
  • Endemic undercounting of cases, including undercounting of COVID-19 infections29,30, which can also skew the data for potential machine learning applications.
  • A baffling array, in many countries, of diverse and incompatible digital healthcare solutions across states, counties, and other segmentations of the population31.
  • Resistance from the medical community related to fears about patient outcome under the burden of substandard EHR32; fears about the increased security risks of digitizing healthcare infrastructure33; a general reluctance, personal and professional, to cede control to machine systems34.
  • Poor provisioning of EHR solutions in competitive, grant-hungry and bid-driven markets35,36,37.  

The United Kingdom's ambitious plans for full patient health data digitization by 202038 resulted in only 10% of NHS trusts achieving paper-free records by 201939. This disappointing result came in the wake of the abandoned £12.7-billion National Electronic Health Record Program in 201240, possibly the most expensive government IT failure in the world at that time41.

Around 2009 in the US, a $30-billion government stimulus package for healthcare digitization42, which might have cohered the country's fragmented health IT sector, was hijacked by the free market: a competitive commercial environment for electronic health records emerged, with rivals eschewing open standards in the hope of market capture through proprietary formats. The result was a multiplicity of non-interoperable EHR systems across US hospitals43.

Although poorer countries face economic barriers to the costs of implementing digitization, the long-term cost reductions are desirable44. In Eastern Europe, where struggling economies make healthcare provision challenging, grants from the European Union are aiding digitization, most notably in the cases of Estonia45 and Poland46.

The Outlook for Healthcare Digitization

The political aspect of healthcare data-gathering and disclosure is difficult to solve, particularly where it reveals inequalities. If the route to saving lives and money with machine learning is via naked disclosure of real-world healthcare data/statistics (which may upset governments' more favorable interpretations), the key to progress may be more diplomatic than scientific in nature. Misleading government management of healthcare data systems and statistics predates the pandemic47,48 and, sadly, seems likely to survive it.

Meanwhile, competitive market forces fragment EHR deployment into multiple non-interoperable networks, particularly in the United States, where federal public health IT proposals must also endure the arguable stigma of 'socialized  medicine'49,50. In a culture where state/private partnerships have co-opted state provisioning51, the retarding effects of the free market on healthcare data digitization seem likely to continue after COVID-19, particularly in the US.

If a single large country cannot standardize an EHR system, a global standard seems even more unlikely. The best solution may be cross-systems translation matrices that use robotic process automation (RPA) to extract and homogenize variously-sourced data for the purposes of training AI healthcare and medical research models. Federated solutions may also help, as we'll see later.

If a single large country cannot standardize an EHR system, a global standard seems even more unlikely.
Tweet

Data Governance, Privacy and Security in Healthcare Data Science

Public ambivalence and consumer fears52,53 regarding the growing digitization and sharing of health data center mainly on the possibility that health insurance companies will somehow obtain privileged patient information in order to raise costs for coverage against particular conditions or pre-existing genetic markers in individual patients — or even for broader geographical swathes of patients, where research identifies specific health issues in a neighborhood, town or state54,55,56.

Healthcare's Move from Actuarial to Social Science Data

While insurance rate increases can be explained and justified with actuarial tables, the black-box nature of machine learning presents a novel legal obstacle.

Healthcare companies are rising to this challenge: a new study57 from the US uses the Python package SHAP to break down the logic of healthcare premium price rises that are calculated with machine learning methods.

Another machine learning project58 can also demonstrably identify potential high-cost claimants (HiCCs) at a 91% accuracy by scraping publicly available data in an explicable and accountable fashion.  

That healthcare insurance providers are keen to switch from actuarial to user-specific data, and that they are willing to use data mining and other oblique techniques to justify increased premiums, has become clear in recent years.

For instance, it was revealed in 2014 that patient information in the UK was repeatedly sold to 178 private health insurance companies59, leading to a change in the law60 but also long-term financial implications for those affected.

Two years later it was discovered that the Google/DeepMind AI project had obtained a far wider access to the data of millions of UK patients than had been anticipated in an earlier deal with the UK government61

Companies in the US openly vaunt their ability to merge information from data brokers with actuarial data, in order to identify individual health data and case histories62, while insurance companies are publiclymoving from actuarial to socially mined data via providers such as LexisNexis63.

The migration from actuarial data is occurring on the pretext of improved early intervention64, health risk prediction65, and fraud prevention66. However, research has found67 that these legitimate business uses of web-scraping and other mining techniques can lead to the leveraging of personal health information (PHI) for the purposes of raising consumer premiums.

Gaining Healthcare Data by Stealth and Opportunism

Where anonymization is used in health databases, re-identification can be achieved by cross-referencing the database with another database (such as a voter register) created for a different purpose. This is similar to the way that advertising companies track web-users across domains68 to facilitate targeted marketing.

Two such databases may each be legal and legitimate in scope, regulation and intent; but cross-referencing them can enable re-identification of anonymized data69 — a use likely not permitted under the acquisition terms of either dataset.

In the United States and elsewhere, legislation against such abuses has proved easier to implement than enforce. In the US, the HIPAA act of 199670 and the HITECH Act of 200971 were conceived, respectively, to address governance and security concerns regarding the use of PHI in machine systems and networks.

In Europe this issue has been covered72,73 by the GDPR since 2018, and with varying levels of governmental commitment in other frameworks around the world74 over the last few decades.

Healthcare Security Breaches Disarm Legislation

The reach of such laws has been undermined not only by the aforementioned impediments to digitization, but the way that the digitization process massively increases the attack surface for healthcare infrastructure:

  • Public healthcare institutions in the US are enduring year-on-year waves of ransomware attacks75 as the rate of digitization and network-facing data systems grows, with the U.S. Cybersecurity and Infrastructure Security Agency anticipating a greater rise in incidents76.
  • A DNA testing service had 92 million accounts breached in 2018, leading to fears77 that the stolen data could end up in the hands of insurance companies, if only because publication puts it into the public domain and into the path of insurers' web-scraping and data mining activities.
  • The U.S. Department of Health and Human Services Office for Civil Rights currently lists 686 data breaches of health-related companies78. The list only reports the previous 24 months, and only covers the United States.
  • In 2017, a report on cyber-incursions on healthcare providers detailed the sale of PHI on the deep web, and the common exploitation of unsecured medical IoT devices and networked printers in health-related environments79

Stolen health data is frequently posted into the public domain, either as punishment for non-payment of ransoms, or as an anarchic act. Mismanagement and poor security practices can also lead to inadvertent publication of PHI80,81,82. In all cases, there's no way to repair the damage done.

Possible Solutions for Healthcare Data Governance, Privacy and Security

Governmental Mandates and Legislation

In the US, there are currently no federally mandated security procedures for healthcare or other sectors83. While stronger laws around the world (such as the GDPR) puts companies at greater default liability for poor security practices, the best of them do little more than insist on secure encryption protocols. However, some governments actively seek to undermine even this minimal safeguard84,85,86.

In fact, social engineering and poorly-designed network infrastructure, among other factors87, frequently play a more important role in healthcare data incursions88.

Internationally and on a state-by-state basis in the US, varying statutory provisions exist to limit price optimization by insurance companies, among the most effective being California's Proposition 103 (1988)89. Such legislation enshrines the actuarial approach against any better and later technologies (including machine learning), and enforces this for social and economic reasons.

Clearly the quality and scope of legislation must be updated to address new issues arising from machine learning: in Sweden, the Analytic Imaging Diagnostics Arena (AIDA) has recently begun to develop a new legislative framework90 to address healthcare data sharing in the AI era, while a similar proposal out of Stanford91 attempts to clarify the extent to which patient data can be commercialized.

New initiatives like this would seem to be a necessary step for all countries that currently rely on older laws to govern newer technologies.

Siloed Institutions for PHI Processing

Air-gapped networks92 are often used by sensitive industries such as nuclear power, air traffic control, and the military, though it's not an unsolvable problem for determined hackers93 and does not remove the possibility of social engineering attacks.

However, with appropriate funding and popular support, this approach can work: the private/public partnership behind the Danish National Genome Center (DNGC) sets a high standard for state governance of sensitive medical data: only one copy of a patient's genetic data exists in the center94, which cannot be copied or erased and will never be allowed to cross borders95.

The DNGC is not just a 'data center' for PHI, but operates many research initiatives under the protection of the same level of state-led governance that ordinarily encompasses tax information, driving licenses, and other civic functions precluded from the private sector.

That said, transferring this concept from a small country like Denmark to a larger one like the USA would entail the creation of a well-funded organization on a scale equivalent to the CDC — with a predictable accompanying gauntlet of political and public objection around costs and the de-emphasis of private sector participation.

Machine Learning Approaches

In theory, machine learning can solve its own problems in this respect96. In July 2020, new research into federated learning proposed a system where multiple institutions contribute data 'blindly' into machine learning models97. Under this approach, all participants benefit from the entirety of the results without gaining access to the other contributing databases.

Federated learning

In this case, the black-box nature of neural network data models serves as an aide to security, since the resulting algorithms will be too abstracted to deconstruct.

Other AI-based approaches include:

  • PrivPy98, a secure multi-party computation (MPC) framework for machine learning tasks.
  • SecureML99, a system of protocols to preserve privacy in machine learning tasks.
  • An edge-based framework to prevent centralization of healthcare data on the cloud100

Conclusion

Left entirely to market forces, the evolution of AI-driven machine learning in the healthcare sector risks to reduce global healthcare availability through increased premiums, and turn the known social benefits of affordable coverage into a genetic lottery, among many other potentially negative effects.

However, the technologies that enable this arguable abuse of knowledge also have the potential to prolong and improve life. Society must navigate and mitigate this conflict through legislation that balances a reliance on market forces against the hard-won tenets of civilization. Though many of the specific challenges around this are technical, the central problem is ethical and sociological in nature.

The central problem of the AI evolution in healthcare is ethical and sociological in nature.
Tweet
Content type
Blog
Partner with Iflexion
to find the workarounds for your AI challenge

WANT TO START A PROJECT?

It’s simple!

Attach file
Up to 5 attachments. File must be less than 5 MB.
By submitting this form I give my consent for Iflexion to process my personal data pursuant to Iflexion Privacy and Cookies Policy.